Stephen M. Kanne

PhD, ABPP

Professor

Executive Director, Thompson Center for Autism & Neurodevelopmental Disorders

William & Nancy Thompson Endowed Chair in Child Health

Educational Background:

  • B.A., Psychology, Washington University (1985)
  • Predoctoral Internship Program, UCSD/VAMC (1998)
  • Ph.D. Clinical Psychology, Specialty in Neuropsychology, Washington University (1999)
  • Postdoctoral Fellowship, University of Missouri, Columbia; Pediatric Neuropsychology

Brief Bio: Dr. Stephen Kanne is a pediatric neuropsychology leading one of the nation’s premier autism research, training and clinical institutions. He is an expert diagnostician for autism spectrum disorders. Dr. Kanne is a nationally certified independent trainer for the gold-standard diagnostic tests for autism – the Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R) – and has trained and presented to clinicians throughout the U.S. and internationally. His research includes the genetics of autism, clinical presentations of autism, measuring the effectiveness of screening and treatment methods in autism, and co-morbid conditions and developmental challenges in individuals with autism.

Research Interests:

Effectiveness measures for autism treatment

Autism screening measures

Genetic bases of autism

Multisystemic therapy in autism

Comprehensive autism care models

Selected Grants:

Principal Investigator (5% FTE), Simons Foundation Autism Research Initiative Clinical Site Network. Funding. Funding Agency: Simons Foundation; Funding Amount (Direct): $450,000 (2016-2019).

Principal Investigator (4 % FTE), Simons Foundation Autism Research Initiative Clinical Site Network Pilot. Funding Agency: Simons Foundation; Funding Amount (Direct): $37,500 (2016).

Principal Investigator (5% FTE), Evaluation of the Cognoa ASD Screening Measure for Use in clinical triage. Funding Agency: Cognoa Inc.; Funding Amount (Direct): $177,253 (2016).

Co- Principal Investigator (10% FTE), The Autism Impact Measure: A New Tool for Treatment Outcome Measurement. (PI: Micah Mazurek). Funding Agency: NIH (1 R01 MH097726-01); Funding Amount (Direct): $2,528,062 (2013–2016).

Co- Principal Investigator (1% FTE), Autism Treatment Network: Cooperative Multi-Center Program for Comprehensive Care and Treatment of Autism (PI, Kristin Sohl). Funding Agency: Autism Speaks; Funding Amount: $870,000 (2011-2017).

Principal Investigator (5% FTE), Autism Spectrum Disorder (ASD) Waitlist Reduction and Training Services.  Funding Agency: Contract with the Department of Mental Health/Division of Developmental Disabilities, $911,428 annually, 07/01/2012- Ongoing.

Principal Investigator (5% FTE), Autism Spectrum Disorder (ASD) Rapid Response Initiative.  Funding Agency: Contract with the Missouri Department of Mental Health/Division of Developmental Disabilities, $103,000 annually, 07/01/2012- Ongoing.

Principal Investigator (15% FTE), Training Experts in Autism for Missouri.  Funding Agency: Contract with the Department of Mental Health/Division of Developmental Disabilities, $440,000 annually, 07/1/2013- Ongoing.

Principal Investigator (5% FTE), Autism Treatment Network: Cooperative Multi-Center Program for Comprehensive Care and Treatment of Autism (Co-PI: Diane Treadwell-Deering). Funding Agency: Autism Speaks; Funding Amount: $75,000 (2011-2014).

Co- Principal Investigator (50% FTE), Simons Variation in Individuals Project (PI: Robin Kochel). Funding Agency: Simons Foundation; Funding Amount: $376,919 (2010-2011).

Principal Investigator (10% FTE), The Autism Impact Measure: A new tool to measure treatment outcome in ASD (Co-PI, Micah Mazurek). Funding Agency: Autism Intervention Research Network on Physical Health; Funding Amount: $112,579. (2010-2011).

Principal Investigator (10% FTE), Adaptation of Multisystemic Therapy for Autism (Co-PI, Micah Mazurek). Funding Agency: University of Missouri, Columbia Research Board; Funding Amount: $50,000. (2010-2011).

Co-Investigator, The Neural Correlates of Inhibitory Control in Individuals with Autism. (PI: Shawn Christ, Ph.D.) Funding Agency: Thompson Center for Autism and Neurodevelopmental Disorders; Funding Amount: $50,000 (2007-2008).

Co-Investigator, Using home videos to identify infants who are later diagnosed with Autism: A retrospective study. (PI: Rebecca McCathren, Ph.D.) Funding Agency: Thompson Center for Autism and Neurodevelopmental Disorders; Funding Amount: $10,000) (2007-2008).

Co- Principal Investigator (29% FTE), Simons Site Application & Autism Dysmorphology Measure Validity Study (PI, Judith Miles). Funding Agency: Simons Foundation; Funding Amount: $1,600,000 (2008-2010). Site Supervisor.

Co- Principal Investigator (21% FTE), Autism Treatment Network: Cooperative Multi-Center Program for Comprehensive Care and Treatment of Autism (PI, Judith Miles). Funding Agency: Autism Speaks; Funding Amount: $450,000 (2008-2010).

Co- Principal Investigator (6% FTE), Autism Intervention Research Network for Physical Health (PI, Judith Miles). Funding Agency: Autism Speaks; Funding Amount: $240,000 (2009-2011).

Core Faculty (15% FTE), Tips for Kids Training Grant, (PI:  Tracy Stroud, D.O.).  Funding Agency: Health Research Service Administration-Award #6 T73 MC00022; Funding Amount: $2,000,000 (07/01/04-06/30/11).

Bibliography of Published Works (since 2006):

Bernier, R, Hudac, C., Chen, Q., Zeng, C., Stevens-Wallace, A., Gerdts, J., Earl, R., Berg, J., Wolken, A., Peters, A., Hanson, E., Goin-Kochel, R., Kanne, S., Green-Snyder, L., and Chung, W.,  on behalf of the Simons VIP Consortium (submitted). Developmental Trajectories for Young Children with 16p11.2 Copy Number Variation. Genetics in Medicine.

Green-Snyder, L., D’Angleo, D., Chen, Q., Bernier, R., Goin-Kochel, R., Stevens-Wallace, A., Gerdts, J., Kanne, S., Berry, L., Blaskey, L., Kuschner, E., Roberts, T., Sherr, E., Martin, C., Ledbetter, D., Spiro, J., Chung, W., Hanson, E., on behalf of the Simons VIP Consortium (Submitted). Neuropsychological characterization of child and adult carriers of the 16p11.2 duplication.  Journal of Autism and Developmental Disabilities.

Bernier, R., Steinman, K., Reilly, B., Stevens-Wallace, A., Sherr, E., Pojman, N, Mefford, H., Gerdts, J., Earl, R., Hanson, E., Goin-Kochel, R., Berry, L., Kanne, S., Green-Snyder, L., Spence, S., Ramocki, M., Evans, D., Spiro, J., Martin, C., Ledbetter, D., & Chung, W.,  on behalf of the Simons VIP Consortium (In Press). Clinical phenotype of the recurrent 1q21.1 copy variant. Genetics in Medicine, 1-11.

Nowell, K.P., Schanding, G.T., Kanne, S.M., & Goin-Kochel, R.P. (2015).  Cognitive profiles in youth with autism spectrum disorders: An investigation of base rate discrepancies using the Differential Ability Scales – Second Edition.  Journal of Autism and Developmental Disabilities, 45(7), 1978-1988.

Hanson, E., Bernier, R., Porche, K., Goin-Kochel, R., Green Snyder, L., Snow-Gallagher, A., Wallace, A., Campe, K., Zhang, Y., Chen, Q., D’Angelo, D., Moreno-De-Luca, A., Orr, P., Boomer, K., Evans, D., Kanne, S., Berry, L., Miller, F., Olson, J., Sherr, E., Martin, C., Ledbetter, D., Spiro, J., Chung, W., on behalf of the Simons VIP Consortium (2014). The cognitive and behavioral phenotype of the 16p11.2 deletion in a clinically ascertained population. Biological Psychiatry.

Nishiyama, T. & Kanne S.M. (2014). On the misapplication of the BAPQ in a study of autism. Journal of Autism and Developmental Disorders, 44(8), 2079-2080.

Wagner, D.V., Borduin, C.M., Kanne, S.M., Mazurek, M.O., Farmer, J.E., and Brown, R.M. (2014) Multisystemic Therapy for Disruptive Behavior Problems in Youths with Autism Spectrum Disorders: A Progress Report. Journal of Marital and Family Therapy, 40 (3), 319-331.

Nishiyama, T., Suzuki, M., Adachi, K., Sumi, S., Okada, K., Kishino, H., Sakai, S., Kamio, Y., Kojima, M., Suzuki, S., & Kanne, S. (2014) Comprehensive Comparison of Self-Administered Questionnaires for Measuring Quantitative Autistic Traits in Adults. Journal of Autism and Developmental Disorders, 44(5), 993-1007.

Goin-Kochel, R.P., Esler, A.N., Kanne, S.M., & Hus, V. (2014). Developmental regression among children with autism spectrum disorder: Onset, duration, and effects on functional outcomes. Research in Autism Spectrum Disorders, 8(7), 890-898.

Keefer, A., Mazurek, M., Kanne, S., Freedman, B., Vasa, R., & Kalb, L. (2014). Methodological Considerations When Assessing Restricted and Repetitive Behaviors and Aggression. Research in Autism Spectrum Disorders, 8(11), 1527-1534.

Kanne, S.M., Mazurek, M.O., Sikora, D., Bellando, J., Branum-Martin, L., Handen, B., Katz, T., Freedman, B., Powell, M.P., & Warren, Z. (2013). The Autism Impact Measure (AIM): Initial development of a new tool for treatment outcome measurement. Journal of Autism and Developmental Disorders, 44(1), 168-179.

Mazurek, M.O., Kanne, S.M., & Wodka, E. (2013). Physical Aggression in Children and Adolescents with Autism Spectrum Disorders. Research in Autism Spectrum Disorders, 7(3), 455-465.

Vasa, R.A., Kalb, L.G., Mazurek, M.O., Kanne, S.M., Keefer, A., Freedman, B., Clemmons, T., & Murray, D. (2013). Age-Related Differences in the Prevalence and Correlates of Anxiety in Youth with Autism Spectrum Disorders. Research in Autism Spectrum Disorders, 7, 1358-1369.

Steinman, K.J., Bernier, R., Berry, L.N., Goin-Kochel, R.P., Johnson, K., Kanne, S.M., Snow, A., Wallace, A., Ramocki, M.B., Spence, S.J., Proud, M.B., Kessler, S.K., Marco, E.J., Sherr, E.H., Chung, W.K., Hanson. E. (2013). Movement Abnormalities and Associated Neurodevelopmental Challenges in Children with 16p11. 2 Deletion or Duplication. Annals of Neurology, 74, S167.

Mazurek, M., Vasa, R., Kalb, L., Kanne, S.M., Rosenberg, D., Keefer, A., Murray, D., Freedman, B., & Lowery, L. (2013). Anxiety, Sensory Over-Responsivity and Gastrointestinal Problems in Children with Autism Spectrum Disorders. Journal of Abnormal Child Psychology, 41(1), 165-176.

Zufferey F, Sherr EH, Beckmann ND, Hanson E, Maillard AM, Hippolyte L, Macé A, Ferrari C, Kutalik Z, Andrieux J, Aylward E, Barker M, Bernier R, Bouquillon S, Conus P, Delobel B, Faucett WA, Goin-Kochel RP, Grant E, Harewood L, Hunter JV, Lebon S, Ledbetter DH, Martin CL, Männik K, Martinet D, Mukherjee P, Ramocki MB, Spence SJ, Steinman KJ, Tjernagel J, Spiro JE, Reymond A, Beckmann JS, Chung WK, Jacquemont S; on behalf of the Simons VIP Consortium,; on behalf of the 16p11.2 European Consortium. (2012). A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders. Journal of Medical Genetics, 49(10), 660-668.

Kanne, S.M., Wang, J.L., Christ, S.E., (2012). The Subthreshold Autism Trait Questionnaire (SATQ): Development of a brief self-report measure of subthreshold autism traits. Journal of Autism and Developmental Disorders, 42 (5), 769-780.

Spiro, J., Chung, W., …Kanne, S., and The Simons VIP Consortium. (2012). Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders. Neuron, 73(6), 1063-1067.

Lord, C, Petkova E., Hus ,V., Gan, W., Lu, F., Martin, D.M., Ousley, O., Guy, L., Bernier, R., Gerdts, J., Algermissen, M., Whitaker, A., Sutcliffe, J.S., Warren, Z., Klin, A., Saulnier, C., Hanson, E., Hundley, R., Piggot, J., Fombonne, E., Steiman, M., Mile, J., Kanne, S.M., Goin-Kochel, R.P., Peters, S.U., Cook, E.H., Guter, S., Tjernagel, J., Green-Snyder, L.A., Bishop, S., Elser, A., Gotham, K., Luyster, R., Miller, .F, Olson, J., Richler, .J, Risi, S. (2012). A Multi-Site Study of the Clinical Diagnosis of Different Autism Spectrum Disorders. Archives of General Psychiatry, 69(3), 306-313.

Mazurek, M., Kanne, S.M., Miles, J. (2012). Predicting improvement in social-communication symptoms of ASD using retrospective treatment data. Research in Autism Spectrum Disorders, 6(1), 535-545.

Kanne, S.M., Gerber, A.J., Quirmbach, L.M., Sparrow, S.S., Cicchetti, D.V., & Saulnier, C.A. (2011). The role of adaptive behavior in autism spectrum disorders: Implications for functional outcome. Journal of Autism and Developmental Disorders. 41 (8), 1007-1018.

Kanne, S., & Mazurek, M. (2011). Aggression in Children and Adolescents with ASD: Prevalence and Risk Factors. Journal of Autism and Developmental Disorders. 41 (7), 926-937

Beversdorf DQ, Saklayen S, Higgins KF, Bodner KE, Kanne SM, Christ SE (2011). Effect of propranolol on word fluency in autism. Cognitive and Behavioral Neurology. 24 (1), 11-17.

Mazurek, M., & Kanne, S. (2010). Friendship and Internalizing Symptoms among Children and Adolescents with ASD. Journal of Autism and Developmental Disorders, 40(12):  1512-1520.

Christ, S., Kanne, S., & Reiersen, A. (2010). Executive Function in Individuals with Sub-Threshold Autism Traits. Neuropsychology, 24 (5), 590-598.

Kanne, S., Christ, S., & Reiersen, A. (2009). Psychiatric Symptoms and Psychosocial Difficulties in Young Adults with Autistic Traits. Journal of Autism and Developmental Disorders, 39(6), 827-833.

Kanne, S., Abbacchi, A., & Constantino, J. (2009). Multi-informant Ratings of Psychiatric Symptom Severity in Children with Autism Spectrum Disorders: the Importance of Environmental Context. Journal of Autism and Developmental Disorders, 39(6), 856-864.

Kanne, S., Randolph, J., & Farmer, J. (2008). Diagnostic and Assessment Findings: A Bridge to Academic Planning for Children with Autism Spectrum Disorders. Neuropsychology Review, 18(4), 367-384.

Mahle, W., Visconti, K., Freier, M., Kanne, S., Hamilton, W, Sharkey, A., Chinnock, R., Jenkins, K., Isquith, P., Burns, T., &. Jenkins, P. (2006).  Relationship of Surgical Approach to Neurodevelopmental Outcome in Hypoplastic Left Heart Syndrome, Pediatrics, 117, 90-97.

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